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The living human heart-on-a-chip for drug safety

Human-relevant preclinical cardiotox screening, without animals

Many promising drugs are dropped, or pulled from the market, because of dangerous effects on the heart. The tests used today either raise false alarms on safe drugs or miss the real danger, and they still rely on slow, costly and ethically controversial animal studies. EasyCard™ is a micro innervated human heart, that shows whether a drug is safe for the heartbeat in just 30 days, at a fraction of the cost, and with zero animals.

30 days
Validated results, not months
+ specific
Fewer false flags than hERG alone
0 animals
for arrhythmia risk assessment

We see what hERG and animals miss.

Today's hERG screening over-flags safe drugs and still misses real risks. EasyCard™ reads the whole human heart, nerves included, so you catch the true dangers and stop killing good candidates for the wrong reason.

Gain #1
Sensitivity
Catch what hERG misses

Terfenadine passed hERG screens yet was pulled from the market. On EasyCard™, its dangerous arrhythmic signature appears only when the heart is innervated. The nerve-heart connection reveals risks that single-cell tests can't see.

+ sensitivity
Gain #2
Specificity
Don't kill safe drugs

Verapamil blocks hERG but is perfectly safe in patients. EasyCard™ reads it correctly: arrhythmic activity stays at baseline, so good candidates aren't killed for the wrong reason. Fewer false positives, less wasted development.

+ specificity
Gain #3
Autonomic risk
See what only animals could see

Some rhythm risks only appear when the nervous system is active. Stimulating the on-chip nerves changes the heartbeat in a real, measurable way (+50% beating rate), letting EasyCard™ reveal autonomic risks that until now only live animal studies could catch.

first in vitro

From first experiment to decision in 30 days.

A single, automated run takes your compound from seeding to a risk readout in one month. No animal study, no multi-month CRO cycle.

Day 0
Set-up
Human heart cells and their nerve cells are placed onto the chip.
Day 0-25
Nerve-heart wiring
The cells grow and connect until the tissue beats and responds like a real heart.
Day 25-30
Dosing & recording
Your molecule is added and the chip records the tissue's electrical activity and contraction at the same time.
Day 30
Analysis & report
You receive a clear heart-rhythm risk readout and full report.

One complete cardiac-safety analysis.

No half-answers. Every study gives you the clear yes/no verdict and the full picture behind it, so you don't just learn whether there's a heart-rhythm risk, but exactly where it comes from. One engagement, one report, the whole story.

The complete analysis
Full cardiac-risk profile
Verdict + the reason behind it

A single study takes your molecule from the go/no-go safety call all the way to the deep dive into why the risk exists. Most tests only tell you if there's a problem. We tell you where it comes from, in the same run, so from the very first month you know whether a molecule is worth pushing forward, what to fix, or what to target to keep its development on track.

Output · clear verdict + full risk profile
What's included
  • Go / no-go verdict: does the molecule carry a heart-rhythm risk?
  • Risk level stratification: regulatory-based risk stratification
  • Nervous-system effect: how the autonomic nerves change the risk
  • Rhythm & rate response: sympathetic surge simulation via electrophysiology stimulation
  • Mechanistic deep-dive: the underlying cause of the signal

A team at the intersection of neuroscience, cardiology, and data.

François-Xavier Desforges, PhD
CEO
Maxime Poinsot, PhD
CTO · Neurobiologist · ENSAM engineer
Nesrine Benslimane, PhD
Lead biologist · hiPSC & co-culture protocols
Lamia Goual, PhD
R&D engineer · biologist

Book a meeting.

Meet us at VivaTech.
Book a slot with the team using the form below.